TRM: A Powerful Two-Stage Machine Learning Approach for Identifying SNP-SNP Interactions
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چکیده
منابع مشابه
Identifying interesting SNP interactions with logicFS
This package contains functions that use logic regression as a wrapper to identify interesting combinations of binary variables and to measure the importance of these interactions. A description of the used methods is given in Schwender and Ickstadt (2006). Even though the intended purpose of this package is the identification of SNP interactions, it can also be applied to other types of binary...
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Most genetic diseases are complex, i.e. associated to combinations of SNPs rather than individual SNPs. In the last few years, this topic has often been addressed in terms of SNP-SNP interaction patterns given as expressions linked by logical operators. Methods for multiple testing in high-dimensional settings can be applied when many SNPs are considered simultaneously. However, another less we...
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The susceptibility of complex diseases are characterised by numerous genetic, lifestyle, and environmental causes individually or due to their interaction effects. The recent explosion in detecting genetic interacting factors is increasingly revealing the underlying biological networks behind complex diseases. Several computational methods are explored to discover interacting polymorphisms amon...
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Prostate cancer (PCa) is one of the most significant male health concerns worldwide. Single nucleotide polymorphisms (SNPs) are becoming increasingly strong candidate biomarkers for identifying susceptibility to PCa. We identified a number of SNPs reported in genome-wide association analyses (GWAS) as risk factors for aggressive PCa in various European populations, and then defined SNP-SNP inte...
متن کاملSNP-SNP interactions as risk factors for aggressive prostate
Prostate cancer (PCa) is one of the most significant male health concerns worldwide. Single nucleotide polymorphisms (SNPs) are becoming increasingly strong candidate biomarkers for identifying susceptibility to PCa. We identified a number of SNPs reported in genome-wide association analyses (GWAS) as risk factors for aggressive PCa in various European populations, and then defined SNP-SNP inte...
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ژورنال
عنوان ژورنال: Annals of Human Genetics
سال: 2011
ISSN: 0003-4800
DOI: 10.1111/j.1469-1809.2011.00692.x